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MR imaging detects metabolic alterations in brain of ADHD subjects

The attention deficit/hyperactivity disorder (ADHD) is the most common neuropsychiatric disorder in children and adolescents. It may persist until the adult age in 30-50% of cases. Among the characteristic traits of the ADHD, there can be found the propensity for risk-taking and the inclination to the abuse of substances and to the gambling. The subjects […]

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Microtubule transport system: a highway between neuronal cell body and synapses

Neuronal cells have developed a characteristic shape, which causes that the distance between the cell body and the synapses is often very long. Therefore, they have a complex and efficient system to transport many proteins from the center to the periphery, and vice versa. The process of transport of proteins from the cell body to […]

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AADC deficiency treatment guidelines

Aromatic L-amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder that leads to a severe combined deficiency of serotonin, dopamine, norepinephrine and epinephrine. Onset is early in life, and key clinical symptoms are hypotonia, movement disorders (oculogyric crisis, dystonia, and hypokinesia), developmental delay, and autonomic symptoms. In this consensus guideline, representatives of […]

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The lysosome signalization function: new mechanisms of neurological diseases

The role and the fame of the lysosomes in cell metabolism are mainly connected to their well-known activity of “garbage collectors”. They are plenty of hydrolytic enzymes that degrade different types of useless macromolecules, thus generating smaller, simpler basic molecules that can enter once again in the flow of the biochemical pathways of the cells. […]

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Brain lactate levels increase in adolescents with depression

The Major Depressive Disorder (MDD) is an important issue for public health. It often appears during the adolescence, and, among the related consequences, suicide is the second cause of death in this age group. Despite its social relevance, however, MDD is far to be understood, and there is some lack of information about its early […]

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Disruption of active zone affects synaptic vesicles only partially

The active zones are specific sites of presynaptic terminals where the docking and the release of synaptic vesicles occur. They are complex, organized protein structures that anchor synaptic vesicles to the plasma membrane. Once bound to the active zone and docked to the plasma membrane, synaptic vesicles can properly respond to the changes of action […]

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