Neurons may remain immature concerning GABAergic neurotransmission in Rett syndrome Abnormal expression of cation chloride cotransporters has been found in the cerebrospinal fluid of patients with Rett syndrome (RTT). This finding suggest an abnormal GABaergic transmission and neuronal maturation. According to these results, neurons of RTT patients could remain “immature” regarding GABA excitability, as it […]
24 posts found
Cellular neurochemistry
Interneuronas, GABA y enfermedades neuropediátricas
What do you know about interneurons? Which processes do you think they regulate? How could dysfunction in interneurons and abnormal gabaergic transmission contribute to the pathophysiology of some neuropaediatric disorders? Interneurons were classically described as short-axon neurons with connections between “input” and “output” principal cells and were recognized for their role in modulating excitability via […]
Cholinergic neurotransmission and the developing brain
What do you know about acetylcholine? What about its role in the developing brain? Are there diseases of the central nervous system due to abnormal cholinergic transmission in paediatrics? Our current knowledge about disorders of neurotransmission in children is focused on transmitters such as dopamine, serotonin or GABA. By contrast little is known about the […]
Serotonin and cortical architecture
The neurotransmitters sculpt the brain Serotonin is an abundant neurotransmitter in the brain. During development, serotonin regulates processes such as neuronal migration and dendrite differentiation through some particular 5HT receptors. Abnormal serotoninergic neurotransmission during early periods of life may disrupt the construction of cortical circuits and contribute to neurologic and neuropsychiatric disorders. The human […]
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