What do you know about acetylcholine? What about its role in the developing brain? Are there diseases of the central nervous system due to abnormal cholinergic transmission in paediatrics? Our current knowledge about disorders of neurotransmission in children is focused on transmitters such as dopamine, serotonin or GABA. By contrast little is known about the […]
24 posts found
Synaptic metabolism
Mitochondrial mobilization controls plasticity and axon formation
LKB1, NUAK1 and SNPH are proteins related to those proceses Courchet, J., et al. Terminal axon branching is regulated by LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell. 2013 (153):1510-1525 Sun, T., et al. Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength. Cell Reports. August 2013 (4):1-7. Axon formation, presynaptic strength and […]
Serotonin and cortical architecture
The neurotransmitters sculpt the brain Serotonin is an abundant neurotransmitter in the brain. During development, serotonin regulates processes such as neuronal migration and dendrite differentiation through some particular 5HT receptors. Abnormal serotoninergic neurotransmission during early periods of life may disrupt the construction of cortical circuits and contribute to neurologic and neuropsychiatric disorders. The human […]
Calcium: is all about control and precision
The precise GABAergic calcium control plays a key role in neuronal plasticity The perisomatic inhibitory control is already known, which can control the action potential output from the post-synaptic cell. The precise level at which this is done, is for the first time described, demonstrating an exquisite compartmentalized control on the heads of dendrite […]
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