Cellular Neurochemistry

The nervous system is made up of different cell populations. These diverse cells interact to create a functioning brain. Understanding this cellular diversity and how they relate to each other is one of the major challenges of modern neuroscience.  The biochemical and molecular specialization of the nervous cells defines function at different developmental stages. In other words, the micro-anatomy of the brain provides the basis for its biochemical and molecular properties, which can vary depending on the age of the child. In this section you will find information about the major components of the nervous system and how they change during neurodevelopment and in relation with different neuropaediatric disorders.

-Neurons

-Glia

-Blood-brain barriers

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23 posts published about Cellular neurochemistry

New roles of microglia in brain pathophysiology

Microglia cells represent, depending on the species, from 5% to 20% of the glial cells in the adult brain. It is commonly accepted that microglia precursors originate in the yolk sac – as the tissue specific macrophages – although their identity has not been confirmed so far. Once the development of the blood-brain barrier is […]

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Anti-inflammatory drugs can reverse synaptic defects

Inflammation modifies risk and/or severity of a variety of brain diseases through still elusive molecular mechanisms. Tomasoni et al. (open access article available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370184/) show that hyperactivation of the interleukin 1 pathway, through either removal of the interleukin 1 receptor 8 (IL-1R8,) or activation of IL-1R, leads to up-regulation of the mTOR pathway and […]

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The diseases of the synaptic vesicles open the way to a new group of neurometabolic diseases

The Inborn Errors of Metabolism (IEM) have normally been considered as the result of errors at the genetic level affecting the biochemical pathways of small molecules such as the neurotransmitters glycine, glutamate, GABA, biogenic amines, etc. The altered concentration of such molecules in the Cerebrospinal Fluid (CSF) have always been used as a diagnostic biomarker […]

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Synaptic metabolism course

A course about synaptic metabolism of the Recordati Rare Disease Foundation will be held in Barcelona, Spain, on November 16 – 18, 2017. Participants are expected to have prior knowledge about the field: practical experience with diagnosis treatment, and/or basic research is recommended. Participants are also expected to present a case report relevant to the theme […]

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