Cellular Neurochemistry

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The nervous system is made up of different cell populations. These diverse cells interact to create a functioning brain. Understanding this cellular diversity and how they relate to each other is one of the major challenges of modern neuroscience.  The biochemical and molecular specialization of the nervous cells defines function at different developmental stages. In other words, the micro-anatomy of the brain provides the basis for its biochemical and molecular properties, which can vary depending on the age of the child. In this section you will find information about the major components of the nervous system and how they change during neurodevelopment and in relation with different neuropaediatric disorders.

-Neurons

-Glia

-Blood-brain barriers

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23 posts published about Cellular neurochemistry

Role of lipids in the secretory pathway

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Exocytosis is an essential cellular activity, particularly evident in neuronal network. The secretion of proteins and other molecules, packed into lipid membranes, or granules, starts in the endoplasmic reticulum (ER), involves the Golgi apparatus, and ends on the surface of the plasma membrane. The transport of molecules to be released outside the cells requires a […]

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Modulation of inhibitory networks by gephyrin

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The glycinergic and the GABAergic neurotransmission are essential inhibitory networks. Glycinergic synapses are mostly present in the spinal cord, brainstem and retina, while GABAergic synapses are preponderant in the fore-brain. Anyway, both types of receptors are often together at post-synaptic regions, thus regulating the neurotransmission at the same time but with different action mechanisms. GABAA […]

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New applications of neuronal 3D cultures help to understand their metabolism

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Scientists have the need to develop and choose the best biological models to understand the basis of the diseases in preclinical studies. Currently, animals and monolayer cell cultures (2D cultures) are widely spread as reference models. Anyway, these models are not completely reliable when it is necessary to comprehend some key events of the development […]

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Los protones también son neurotransmisores

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Investigaciones recientes llevadas a cabo por Du y colaboradores, muestran que los protones cumplen criterios para ser considerados neurotransmisores. Éstos son liberados desde la neurona presináptica y activan un tipo especial de receptores post-sinápticos, los canales iónicos sensibles al medio ácido, o ASICs (acidsensing ion channels). Se trata de canales permeables al Na+ y al Ca2+ que son activados por la acidosis extracelular.

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