Development and Differentiation

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The complex diversity of nervous cells and functional interconnections in circuits are laid down early in development and mature appropriately over time. Neurogenesis, Migration, Axon Guidance, Synaptogenesis, Formation and Myelin Maintenance, Plasticity and Learning, are some of the most important processes that constitute neurodevelopment from early embryonic stages to postnatal life, childhood and adolescence. Growth factors, Neurotransmitters and Signaling Pathways are some of the neurochemical and molecular elements that contribute to brain development and differentiation. In this section you will find information about how these different processes that participate in development and differentiation are impaired in diverse neuropaediatric disorders.

Developing

IN PARTICULAR  DISORDERS

Rett syndrome and GABAertic maturation

ENVIRONMENTAL FACTORS

Adequate care for children protects their brain development

15 posts published about Development and differentiation

DHA: a key omega-3 fatty acid in children brain development

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Docosahexaenoic acid (DHA) is a long-chain omega-3 fatty acid naturally present in cold water fatty fish, and in maternal breast milk. DHA is also available in fish oil, in algal supplements, and in fortified milk and eggs. Although DHA can be synthesized from short-chain precursor a-linolenic acid, diet-assumed DHA accumulates more efficiently in erythrocytes, breast […]

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Official launch of the CGB network

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“Connecting The Growing Brain” http://www.connectingthegrowingbrain.com. Network of paediatric neurologists and basic researchers that aims to understand the developing brain through synaptic communication. Today we are pleased to announce the official launch of the network “Connecting the growing brain” (CGB). We are a group of pediatric neurologists and basic researchers working together to understand how dysfunctions […]

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Abnormal Gabaergic transmission in Rett syndrome

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Neurons may remain immature concerning GABAergic neurotransmission in Rett syndrome Abnormal expression of cation chloride cotransporters has been found in the cerebrospinal fluid of patients with Rett syndrome (RTT). This finding suggest an abnormal GABaergic transmission and neuronal maturation.  According to these results, neurons of RTT patients could remain “immature” regarding GABA excitability, as it […]

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Adequate care for children protects their brain development

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Caregivers’ support is crucial to mitigating negative effects of poverty. Poverty impacts brain development negatively. But if parents provide adequate support they can ameliorate those effects. Reference: Luby J., et al. The Effects of Poverty on Childhood Brain Development. JAMA Pediatr, published online October 28, 2013. Poverty has a deleterious effect on child development and neurocognitive […]

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Serotonin and cortical architecture

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The neurotransmitters sculpt the brain Serotonin is an abundant neurotransmitter in the brain. During development, serotonin regulates processes such as neuronal migration and dendrite differentiation through some particular 5HT receptors. Abnormal serotoninergic neurotransmission during early periods of life may disrupt the construction of  cortical circuits and contribute to neurologic and neuropsychiatric disorders.   The human […]

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