The “International Working Group on Neurotransmitter Related Disorders” (iNTD) includes different centers from Europe, the United States and Asia.
It consists of three Networks.
Network I: the major goal of this network is to set-up a web-based patient registry for inherited defects of neurotransmitter, pterin and folate metabolism. This aims to provide a basis for improving our understanding of the epidemiology, genotype/phenotype correlation and outcome of these diseases, their impact on the quality of life of patients, and for evaluating diagnostic and therapeutic strategies.
The following diseases will be initially included in the registry: Aromatic amino acid decarboxylase (AADC) deficiency, Tyrosine hydroxylase (TH) deficiency, Dopamine beta-hydroxylase (DßH) deficiency, – Monoamine oxidase A (MAOA) deficiency, Dopamine transporter (DAT) deficiency, Vesicular monoamine transporter 2 (VMAT) deficiency, BH4 Deficiencies, Autosomal recessive GTP cyclohydrolase deficiency, Autosomal dominant GTP cyclohydrolase deficiency (Segawa disease), 6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency, Dihydropteridine reductase (DHPR) deficiency, Sepiapterin reductase (SR) deficiency, Cerebral folate deficiencies, Folate receptor alpha (FOLR1) deficiency, Dihydrofolate reductase (DHFR) deficiency.
Network II works on developing of a web-based working-platform and information portal about neurotransmitters, cellular neurochemistry and synaptic communication in neuropaediatric diseases, which is actually this web page.
Network III is focused on defining clinical scales to develop Parkinsonism-Dystonia–Rating-Scales in children.
To know more about this international working group visit the web page iNTD