Intracellular signaling is essential for development, differentiation, survival and plasticity. G Proteins, Cyclic Nucleotides, Calcium, Phosphoinositides, Phosphorylation of different amino acids and Transcription Factors, are the main ways by which cells establish intracellular signaling in the nervous system. In this section you will find information about how these pathways are affected in different neuropaediatric disorders.
Pharmacological chaperones, a new mechanism to protect tyrosine hydroxylase from degradation Tyrosine hydroxylase (TH) is an enzyme that converts the amino acid L-tyrosine into the neurotrasmitter L-DOPA, fundamental for the normal functioning of the nervous system. Mutations in the gene that codes for TH cause a reduction in enzyme activity and are associated to disorders like tyrosine hydroxylase deficiency (THD), Parkinson’s disease and Alzheimer’s disease. For […]
Investigaciones recientes llevadas a cabo por Du y colaboradores, muestran que los protones cumplen criterios para ser considerados neurotransmisores. Éstos son liberados desde la neurona presináptica y activan un tipo especial de receptores post-sinápticos, los canales iónicos sensibles al medio ácido, o ASICs (acidsensing ion channels). Se trata de canales permeables al Na+ y al Ca2+ que son activados por la acidosis extracelular.
Glutamatergic receptor disorders in children What do you know about glutamatergic transmission? What kind of neuropaediatric disorders are related to glutamatergic receptor mutations? What kind of symptoms could be associated with abnormal glutamatergic transmission? Glutamate is the most abundant excitatory neurotransmitter in the nervous system and it plays a key role in long-term potentiation (LTP). LTP is involved […]
Official launch of the CGB network “Connecting The Growing Brain” http://www.connectingthegrowingbrain.com. Network of paediatric neurologists and basic researchers that aims to understand the developing brain through synaptic communication. Today we are pleased to announce the official launch of the network “Connecting the growing brain” (CGB). We are a group of pediatric neurologists and basic researchers working together to understand how dysfunctions […]
Mitochondrial mobilization controls plasticity and axon formation LKB1, NUAK1 and SNPH are proteins related to those proceses Courchet, J., et al. Terminal axon branching is regulated by LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell. 2013 (153):1510-1525 Sun, T., et al. Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength. Cell Reports. August 2013 (4):1-7. Axon formation, presynaptic strength and […]
Connecting the growing brain network of specialised clinicians and researchers. People and labs around the world with the aim to understand the developing brain through synaptic communication.
