Nonketotic hyperglycinemia (NKH) is a rare genetic disorder caused by a defect in the machinery for the breakdown of the amino acid glycine . Above all, it is a very complex disease, since it does not affect all the patients the same way. Because of the huge differences observed in the outcome, researchers from United […]
Posts with tag 'inhibitory neurotransmission'
Sleep traps memory. The role of dopamine
With only 100,000 neurons, the fruit fly Drosophila Melanogaster confirms that sleep is not only good for skin and mood, but also for memory. American researchers at Florida Campus of The Scripps Research Institute published in the journal Cell that remembering and forgetting are two processes closely related, dependent on the activation or inactivation of […]
Abnormal Gabaergic transmission in Rett syndrome
Neurons may remain immature concerning GABAergic neurotransmission in Rett syndrome Abnormal expression of cation chloride cotransporters has been found in the cerebrospinal fluid of patients with Rett syndrome (RTT). This finding suggest an abnormal GABaergic transmission and neuronal maturation. According to these results, neurons of RTT patients could remain “immature” regarding GABA excitability, as it […]
Calcium: is all about control and precision
The precise GABAergic calcium control plays a key role in neuronal plasticity The perisomatic inhibitory control is already known, which can control the action potential output from the post-synaptic cell. The precise level at which this is done, is for the first time described, demonstrating an exquisite compartmentalized control on the heads of dendrite […]