62 posts found

Disruption of active zone affects synaptic vesicles only partially

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The active zones are specific sites of presynaptic terminals where the docking and the release of synaptic vesicles occur. They are complex, organized protein structures that anchor synaptic vesicles to the plasma membrane. Once bound to the active zone and docked to the plasma membrane, synaptic vesicles can properly respond to the changes of action […]

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Truncated glycine transporter 1 causes a novel subtype of NKH

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Glycine is the simplest amino acid and a fundamental neurotransmitter in the central nervous system (CNS). Its activity is mainly inhibitory in caudal regions of CNS, but it also has a co-agonist role at a specific subtype of glutamate receptors present throughout the CNS. Extracellular glycine levels are regulated by two types of transporters, called […]

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Adenosine receptors may help neuronal regeneration

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A fundamental step in neuronal development is constituted by the axonal growth and the dendritic branching. Many intra- and extra-cellular signals regulate this process, indeed is very important that the growth of neuronal extremities follow a precise direction in order to reach their target cells. The distal tip of the axon is a specialized structure […]

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Role of lipids in the secretory pathway

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Exocytosis is an essential cellular activity, particularly evident in neuronal network. The secretion of proteins and other molecules, packed into lipid membranes, or granules, starts in the endoplasmic reticulum (ER), involves the Golgi apparatus, and ends on the surface of the plasma membrane. The transport of molecules to be released outside the cells requires a […]

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