The role and the fame of the lysosomes in cell metabolism are mainly connected to their well-known activity of “garbage collectors”. They are plenty of hydrolytic enzymes that degrade different types of useless macromolecules, thus generating smaller, simpler basic molecules that can enter once again in the flow of the biochemical pathways of the cells. […]
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Posts with tag 'professionals'
Disruption of active zone affects synaptic vesicles only partially
The active zones are specific sites of presynaptic terminals where the docking and the release of synaptic vesicles occur. They are complex, organized protein structures that anchor synaptic vesicles to the plasma membrane. Once bound to the active zone and docked to the plasma membrane, synaptic vesicles can properly respond to the changes of action […]
Truncated glycine transporter 1 causes a novel subtype of NKH
Glycine is the simplest amino acid and a fundamental neurotransmitter in the central nervous system (CNS). Its activity is mainly inhibitory in caudal regions of CNS, but it also has a co-agonist role at a specific subtype of glutamate receptors present throughout the CNS. Extracellular glycine levels are regulated by two types of transporters, called […]
Adenosine receptors may help neuronal regeneration
A fundamental step in neuronal development is constituted by the axonal growth and the dendritic branching. Many intra- and extra-cellular signals regulate this process, indeed is very important that the growth of neuronal extremities follow a precise direction in order to reach their target cells. The distal tip of the axon is a specialized structure […]
Synapses dysfunction and synaptopathies
The concept of synaptopathy refers to any brain disorder related with the impairment of synaptic junctions. Indeed, this definition does not really distinguish whether synaptic dysfunction is the cause or the consequence of such disorders, and often knowing where and when the onset of a disease occurs it is not clear. What is clear is […]
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